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Though unlikely, there is also a risk of hypoglycemia, as semaglutide reduces blood glucose levels

36 In another phase 1, randomized, single-blind, placebo-controlled safety trial, Bajaj and colleagues 37 studied the use of oral FMT capsules in patients with cirrhosis and recurrent HE

While behavioral adaptation may contribute, physiologic changes likely play a role as well

How PlexusDx Supports a More Personalized Approach PlexusDx's Precision Peptide Genetic Test examines genetic variants in GLP-1 and metabolic pathways (GLP1R rs6923761, FTO rs9939609) that may provide context for an individual's metabolic response to GLP-1 therapy

Downstream effects include fatigue, plateaus, injury risk, and a harder rebound after discontinuation